Role of nicergoline in corneal wound healing in diabetic rats

Abstract Background To investigate the effect of nicergoline on rate complete corneal ulcer reepithelialization (CCUR) in diabetic rats with keratopathy. Methods Forty-eight streptozotocin-induced were randomly divided into two groups. The experimental group ( n = 24) received (10 mg.kg − 1 .day ), while control (n a placebo. A epithelial defect was induced using diamond burr, and area compared at time points 0, 12, 24, 48 72 h after injury image analysis software. probability CCUR within assessed Kaplan–Meier survival log-rank test. Results When compared, 4 24 (17%) placebo 12 (50%) found to have (log-rank 0.027). Cox regression no covariates blood glucose P 0.601) or weight 0.322) (survival) curve. Conclusions Nicergoline increased wound healing rates relative may therefore be investigated as treatment option